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Members

Please find detailled information on the members of the CARID Forum here.

Members

Work Group Leader "Kardiovaskuläre Degeneration" (Cardiovascular Degeneration)

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Senior Consultant for Cardiac Surgery, Head Mechanical Circulatory Support Programme, Head CURE- 3D Lab, Head Digital Health Lab Düsseldorf

Head of the Junior Research Group of the CRC 1116 at the Institute of Pharmacology

  • Publication List
    see publication list
     
  • Research Topics
    My main research focuses on the interaction between the heart and adipose tissue lipolysis in different cardiac pathologies such as myocardial infarction, cardiac hypertrophy, and heart failure. Here, the focus is on the effects of mentioned cardiac pathologies on the different white adipose tissue depots, in particular on the activation of lipolysis and adipocyte triglyceride lipase (ATGL), and vice versa, on the effects of adipose tissue lipolysis on cardiac metabolism, cardiac remodelling and the different cell types involved in remodelling, such as fibroblasts and immune cells. The aim is to identify possible new therapeutic strategies. These interactions will then be comparatively investigated in the context of metabolic co-morbidities such as type 2 diabetes mellitus. Furthermore, I am interested in the field of next-generation sequencing methods, especially in the spatiotemporal analysis of changes in cardiac metabolism after myocardial infarction using spatial transcriptomics.

Head of the Myocardial Infarction Research Laboratory

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Scientific director and head of the research group "Experimental Vascular Medicine" at the Department of Vascular and Endovascular Surgery

Provisional Head of the Institute of Molecular Cardiology

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Head of the CVRL - Cardiovascular Research Laboratory

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Work Group Leader "Kardiovaskuläre Degeneration" (Cardiovascular Degeneration)

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Research associate at the Institute for Cardiovascular Physiology

  • Self-introduction
    My professional career is essentially characterised by two aspects: On the one hand, by my studies in human medicine and subsequent clinical work, particularly in the field of anaesthesiology, and on the other hand, by my scientific, preclinical research, which took place, among other things, within the framework of a PhD programme at the University of Amsterdam. Since 2013, I have been working at the Institute of Cardiovascular Physiology, where one focus of my work as a research group leader is the cardiac characterisation of various preclinical disease models. These include, for example, cardiac remodelling based on myocardial I/R damage or cardiac changes in (pre-)diabetic metabolic conditions. In addition to the analysis of cardiovascular function using various in vitro and in vivo methods (echocardiography, PV catheter of the left ventricle, isolated perfused heart ...), one focus of my interest is on investigations of cardiac metabolism in the context of pathophysiological processes. For example, we perform respirometric measurements on isolated cardiac mitochondria, but we have also just developed a new method of extracellular flux analysis (Seahorse) in intact heart tissue sections. This enables an in vitro observation of the substrate metabolism of myocardial tissue, in which cell integrity and tissue architecture are preserved. Thus, the influence of cell-cell interactions is preserved.

Scientist at the Institute of Molecular Cardiology

  • Publication List
    see publication list
     
  • Self-Introduction
    In the wide field of research on cardiac healing after myocardial infarction, I am especially interested in the role of cardiac stromal cells (fibroblasts) in intercellular crosstalk. I am involved in projects that explore pathways regulating their activity (e.g. adenosine-A2BR signaling, HIF-1α signaling) as well as paracrine factors they provide to communicate to other cell types to promote tissue protection and repair (e.g. IL-6, MCP-1, VEGF, IGF). Methods we use include extracellular and intracellular purine metabolomics (HPLC), gene expression analysis (qRT-PCR, single-cell RNA sequencing), protein analysis (immunofluorescence, flow cytometry, Western Blot, SILAC mass spectrometry, multiplex cytokine assay), Langendorff-based cell isolation, in vitro model of mechanical stress (cell stretching system), in vitro model of hypoxia (CO2 incubator with O2 control).

Head of the Department of Coronary Vascular Cardiology and Conservative Intensive Care Medicine, head of the TAVI program (Transcatheter Aortic Valve Implantation) and head of the Cardiac-Arrest-Center

Institute of Molecular Medicine III
Work Group "Cardiovascular Sphingolipid Research"

  • Curriculum Vitae
    see curriculum vitae
     
  • Self-Introduction
    I am working on the role of sphingosine-1-phosphate (S1P) and related metabolites in the physiology and pathophysiology of the cardiovascular system.
    S1P is a sphingolipid that can also serve as a "second messenger." It affects a variety of cellular processes in different organ systems via its 5 receptors.
     
  • Research Interests
    Effect of S1P, S1P receptors as well as S1P transporters
    - on cardiomyocytes after ischemic events
    - on vascular remodeling
    - on development and progression of abdominal aortic aneurysms

    Publication List
  • see publication list

Professor at the Institute of Cardiovascular Physiology

Senior physician and specialist for radiology at the Institute of Diagnostic and Interventional Radiology

Managing senior physician of the Department of Anaesthesiology and Surgical Intensive Care Medicine

Senior physician of the Section for Heart Failure, Emergency and Rescue Medicine, Medical Director of the Cardiovascular Research Lab, Head of the Outpatient Cardiology Centre, Head of the Outpatient Cardiology Centre

  • Curriculum Vitae
    see curriculum vitae
     
  • Publication List
    see publication list
     
  • Research Focus
    The scientific focus of PD Dr. Polzin's research group is translational cardiology, ranging from basic research to clinical studies. He is primarily concerned with the components of cellular and plasmatic coagulation and lipids. These fields are being studied in detail in the context of metabolism, as well as in various animal models and human cohorts such as myocardial infarction, heart failure or structural heart disease.
    In his clinical work, PD Dr. Polzin is Head Physician of the Department of Heart Failure, Emergency and Rescue Medicine, and the Outpatient Cardiology Center, as well as Medical Director of Patient Management and the Cardiovascular Research Lab of the Department of Cardiology, Pulmonology and Vascular Medicine.

    Open the website of the research group Polzin
     
  • Social Media

Head of the research group "AG CARECOMM  - Cardiac Remodeling: Confounders and Molecular Mechanisms" at the Department of Anesthesiology

Senior physician and specialist in radiology at the Institute of Diagnostic and Interventional Radiology

Senior physician at the Department of Cardiac Surgery

Guest scientist at the Institute of Neuro- and Sensory Physiology

Research group leader at the Institute of Pharmacology

Managing Senior Physician at the Department for Nephrology

Biologist (M.Sc.) at the Institute of Pharmacology

  • Curriculum Vitae
    see curriculum vitae (DE / ENG)

Senior postdoctoral scientist with a

  • Research Focus on:
    • The mechanisms of endothelial (dys)function and regulation of vascular tone and blood pressure
    • Interrelationships of hyaluronan and NO-signaling in health, cardiovascular and metabolic disease states
    • The role of hyaluronan-rich extracellular matrix (ECM) in cardiovascular, metabolic, and immune response to exercise
    • The role of hyaluronan-rich extracellular matrix (ECM) in cardiovascular, metabolic, and immune response to exercise
       
  • Publication List
    see publication list

Leader of the Research Group "Molecular Imaging" at the Department of Anaesthesiology

Professor Twarock's introduction will soon be available here.

Senior physician, specialist for vascular surgery, endovascular surgeon DGG
Head of the Research Group "Aortic Lesions"

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Head of the lab CURE3D Laboratory, Clinic of heart surgery, University Hospital Düsseldorf

  • Curriculum Vitae
    see     curriculum vitae
     
  • Self-Introduction
    As the head of the CURE3D laboratory at the Clinic for Cardiac Surgery, I am dedicated to exploring new and exciting technologies like 3D cell cultures and tissue engineering in my research. I am particularly interested in decoding the impact of cardiac adipose tissue and metabolic disorders on cardiovascular diseases and heart failure.
    My academic career began at the University of Konstanz, where I also completed my PhD at the Institute of Biochemistry. There, I studied an oncogenic protein of the human papillomavirus. I expanded my scientific skillset during my postdoctoral fellowship in Sweden at the Department of Clinical Virology. During this time, I extensively studied a Biosafety Level 3 virus (Tick Born Encephalitis Virus). I collaborated closely with the Helmholtz Institute for Infection Research in Braunschweig to investigate the influence of the immune system on this neurotrophic disease. During my second postdoc at the LIMES Institute in Bonn, I developed a 3D adipose tissue with functional immune cells. This enabled me to gain unique insights into the relationship between adipose tissue, metabolism, and heart health using patient-specific samples and adult stem cells at CURE3D.
     
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